Aki Manninen currently works at the Center of Cell-Matrix Research, University of Oulu. Aki does research in Cell Biology, Cancer Research and Molecular Biology. Their current project is.
Three-dimensional (3D) organoids provide a new way to model various diseases, including cancer. We made use of recently developed kidney-organ-primordia tissue-engineering technologies to create novel renal organoids for cancer gene discovery. We then tested whether our novel assays can be used to examine kidney cancer development. First, we identified the transcriptomic profiles of quiescent.
Currently, three different off-loading techniques are used in humans: silicone gel sheets, paper tape and embrace advanced scar therapy 2.. 1 Oulu Center for Cell-Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland 2 Biocenter Oulu, University of Oulu, Oulu, Finland 3 Department of Biomedicine, University of Bergen, Bergen, Norway 4 Centre for.
Cell Segmentation Proposal Network For Microscopy Image Analysis Saad Ullah Akram 1;2, Juho Kannala3, Lauri Eklund 4, and Janne Heikkil a 1Center for Machine Vision and Signal Analysis, 2Biocenter Oulu, 4Faculty of Biochemistry and Molecular Medicine, and 4Oulu Center for Cell-Matrix Research, University of Oulu, Finland 3 Department of Computer Science, Aalto University, Finland.
Oulu Center for Cell-Matrix Research, University of Oulu, FIN-90014 Oulu, Finland 3 Department of Experimental Medicine, University of Rome “Sapienza”, 00164 Rome, Italy.
Tissue, organ and organoid cultures provide suitable models for developmental studies, but our understanding of how the organs are assembled at the single-cell level still remains unclear. We describe here a novel fixed z -direction (FiZD) culture setup that permits high-resolution confocal imaging of organoids and embryonic tissues. In a FiZD culture a permeable membrane compresses the.
Experimental Research of Dynamic Instabilities in the Presence of Coiled Wire Inserts on Two-Phase Flow. Recent Advances in the Surgical Treatment of Differentiated Thyroid Cancer: A. Recent Advances in the Surgical Treatment of Differentiated Thyroid Cancer: A Comprehensive Review. Distribution and Bioconcentration of Polycyclic Aromatic Hydrocarbons in. Distribution and Bioconcentration.
Born to sense: biophysical analyses of the oxygen sensing prolyl hydroxylase from the simplest animal Trichoplax adhaerens Kerstin Lippl, Anna Boleininger, Michael A McDonough, Martine I Abboud, Hanna Tarhonskaya, Rasheduzzaman Chowdhury, Christoph Loenarz, Christopher J Schofield Chemistry Research Laboratory, University of Oxford, Oxford, UK Background: In humans and other.
The small GTPase RhoA is a major regulator of actin reorganization during the formation of stress fibers; thus identifying molecules that regulate Rho activity is necessary for a complete understanding of the mechanisms that determine cell contractility. Here, we have identified Arhgap28 as a Rho GTPase activating protein (RhoGAP) that switches RhoA to its inactive form. We generated an.
The amount of hyaluronan (HA) is low in simple epithelia under normal conditions, but during tumorigenesis, trauma or inflammation HA is increased on the epithelial cells and surrounding stroma.
INTRODUCTION. Tissue development depends on orchestrated signaling and crosstalk between the constituent cell types. This crosstalk is required for the synchronization and balancing of several processes, including regulation of the relative amounts of the distinct components that make up the tissue and, largely in parallel, for the regulation of their spatial organization.
Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention.
This volume details widely used and newer lab protocols for studying hypoxic responses in physiology and diseases. Chapters guide the reader through the application of hypoxic conditions, to the techniques of molecular biology, biochemical, cell biology, genomic,bioinformatic, metabolic, and animal studies.
Biocenter Oulu, Infotech Oulu, Center for Cell Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Aapistie 5A, 90220, Oulu, Finland Zenglai Tan, Jingdong Shan.
Oulu Center for Cell-Matrix Research, and Department of Medical Biochemistry and Molecular Biology, 90014 University of Oulu, Finland. Abstract Formation, maturation, stabilization, and functional efficacy of the neuromuscular junction (NMJ) are orchestrated by transsynaptic and autocrine signals embedded within the synaptic cleft.Institute of Health Sciences, University of Oulu, Oulu, FinlandDepartment of Medical Biochemistry and Molecular Biology, Oulu Center for Cell-Matrix Research, Biocenter, University of Oulu, Oulu, Finland See all articles by this author.Background and Aims Early detection of fibrosis is important in identifying individuals at risk for advanced liver disease in non-alcoholic fatty liver disease (NAFLD). We tested whether second-harmonic generation (SHG) and coherent anti-Stokes Raman scattering (CARS) microscopy, detecting fibrillar collagen and fat in a label-free manner, might allow automated and sensitive quantification of.